Featured Publications with GTC Support

Massively Parallel Sequencing

1. Asp P, Blum R, et al. Genome-wide remodeling of the epigenetic landscape during myogenic differentiation. Proc Natl Acad Sci U S A. 2011 May 31;108(22):E149-58. 
2. Tchou-Wong K.M. et al., Effects of nickel treatment on H3K4 trimethylation and gene expression. PLoS One. 2011, 6(3):e17728.
3. Roignant, J.Y. and J.E. Treisman, Exon Junction Complex Subunits Are Required to Splice Drosophila MAP Kinase, a Large Heterochromatic Gene. Cell, 2010. 143(2):238-50.
4. Chong MM, et al. Canonical and alternate functions of the microRNA biogenesis machinery. Genes Dev. 2010, 24(17):1951-60.

Microarrays

1. Nguyen D.H. et al., Radiation Acts on the Microenvironment to Affect Breast Carcinogenesis by Distinct Mechanisms that Decrease Breast Cancer Latency and Affect Tumor Type. Cancer Cell, 2011 May 17;19(5):640-51.
2. Klinakis A., Lobry C. et al, A novel tumor suppressor function for the Notch pathway in myeloid leukemia. Nature, 2011 May 12;473(7346):230-3.
3. Huh J.R. et al, Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. Nature. 2011 Apr 28;472(7344):486-90.
4. Manel N. et al., A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature. 2010, 467(7312):214-7.
5. Reavie, L., et al., Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Nat Immunol, 2010.
6. Flaherty, M.S., et al., Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. Dev Cell, 2010.
7. Buonamici, S., et al., CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature, 2009.
8. Bogunovic, D., et al., Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival. Proc Natl Acad Sci U S A, 2009.
9. Thompson, B.J., et al., Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J Exp Med, 2008.
10. Margueron, R., et al., Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell, 2008.
11. Cardinale, C.J., et al., Termination factor Rho and its cofactors NusA and NusG silence foreign DNA in E. coli. Science, 2008. 

MicroRNA Profiling

1. Zhdanova O, et al. The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy. Kidney Int. 2011 May 4. [Epub ahead of print]
2. Chen JA, et al. Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop. Neuron. 2011 Feb 24;69(4):721-35.
3. Vargova K, Curik N, Burda P, et al. MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. Blood. 2011 Apr 7;117(14):3816-25.
4. Huynh C, et al. Efficient in vivo microRNA targeting of liver metastasis. Oncogene. 2011 Mar 24;30(12):1481-8.