Microscopy Core

Electron Microscopy Light Microscopy

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The Microscopy Core is located on the 2nd floor of the Skirball Institute of Biomolecular Medicine and provides a comprehensive range of light and electron microscopy services. The Electron Microscopy Core provides a full service for sample preparation, ultramicrotomy, cryo-ultramicrotomy, immunolabeling, negative staining & rotary shadowing of macromolecules, and morphological analysis by transmission electron microscopy. The Light Microscopy Core is fully equipped for conventional transmitted light, multiphoton fluorescence, confocal and live cell-imaging. User training and assisted support are offered for both cores.

Electron Microscopy

Established in 2005, the EM Core is equipped with four electron microscopes and related devices and tools. The experienced staff will provide instruction, consultation, assistance, and collaboration for any research involving electron microscopy. Additional specialized techniques are available including high-pressure freezing, freeze-substitution, and electron tomography. Trained and experienced users are permitted to use the core instruments following a fee-per-service basis. New users should contact Alice Liang to discuss their project and imaging requirements.

Light Microscopy

Established in 2009, the LM Core is housed alongside the EM Core and provides a comprehensive range of imaging systems dedicated to bringing state-of-the-art methods in modern light microscopy, including live-cell imaging and image processing. Oversight is provided by Michael Dustin, an Internationally recognized imaging expert, and the highly experienced core staff can provide a broad array of expert services. New users should contact Yan Deng to discuss their imaging requirements and arrange any necessary training.