2010 Archive

• Adams S, Chakravarthy AB, Donach M, Spicer D, Lymberis S, Singh B, Bauer JA, Hochman T, Goldberg JD, Muggia F, Schneider RJ, Pietenpol JA, Formenti SC. Preoperative concurrent paclitaxel-radiation in locally advanced breast cancer: pathologic response correlates with five-year overall survival. Breast Cancer Res Treat. Dec 2010;124(3):723-732. PMID: 20878462.
• Blank SV, Christos P, Curtin JP, Goldman N, Runowicz CD, Sparano JA, Liebes L, Chen HX, Muggia FM. Erlotinib added to carboplatin and paclitaxel as first-line treatment of ovarian cancer: a phase II study based on surgical reassessment. Gynecol Oncol. Dec 2010;119(3):451-456. PMID: 20837357.
• Block ET, Cronstein BN. Interferon-gamma inhibits adenosine A2A receptor function in hepatic stellatecells by STAT1-mediated repression of adenylyl cyclase. Int J Interferon Cytokine Mediator Res. 2010 Oct; 2010 (2):113-126. PMID: 21132069.
• Blum R, Gupta R, Burger PE, Ontiveros CS, Salm SN, Xiong X, Kamb A, Wesche H, Marshall L, Cutler G, Wang X, Zavadil J, Moscatelli D, Wilson EL. Molecular signatures of the primitive prostate stem cell niche reveal novel mesenchymal-epithelial signaling pathways. L. PLoS ONE. 2010;5(9). PMID: 20941365.
• Chong MM, Simpson N, Ciofani M, Chen G, Collins A, Littman DR. Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. Genes Dev. 2010 Apr 1;24(7):659-69. PMID: 20360383.
• Chong MM, Zhang G, Cheloufi S, Neubert TA, Hannon GJ, Littman DR. Canonical and alternate functions of the microRNA biogenesis machinery. Genes Dev. 2010 Sep 1;24(17):1951-60. Epub 2010 Aug 16. Erratum in: Genes Dev. 2010 Oct 1;24(19):2228. PMID: 20713509.
• Connolly MK, Mallen-St Clair J, Bedrosian AS, Malhotra A, Vera V, Ibrahim J, Henning J, Pachter HL, Bar-Sagi D, Frey AB, Miller G. Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor. Journal of leukocyte biology. 2010;87(4):713-725. PMID: 20042467.
• Elbuluk N, Martiniuk F and Levis WR. Erythema nodosum leprosum, Sweet’s syndrome, and HIV may be related through an overlap in immunopathogenesis. Int J Derm, 49, 1344-5, 2010. PMID: 20964666.
• Espinosa L, Cathelin S, D'Altri T, Trimarchi T, Statnikov A, Guiu J, Rodilla V, Ingles-Esteve J, Nomdedeu J, Bellosillo B, Besses C, Abdel-Wahab O, Kucine N, Sun S-C, Song G, Mullighan CC, Levine RL, Rajewsky K, Aifantis I, Bigas A. The Notch/Hes1 pathway sustains NF-B activation through CYLD repression in T cell leukemia. Cancer cell. 2010;18(3):268-281. PMID: 20832754.
• Fooksman DR, Schwickert TA, Victora GD, Dustin ML, Nussenzweig MC, Skokos D. Development and migration of plasma cells in the mouse lymph node. Immunity. 2010;33(1):118-127. PMID: 20619695.
• Fossati S., Cam J.,1, Meyerson J., Mezhericher E., Romero I. A., Couraud P. O., Weksler B. B., Ghiso J. and Rostagno A. Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-β variants in cells composing the cerebral vessel walls. FASEB J. 2010 Jan;24(1):229-41. Epub 2009 Sep 21. PMID: 19770225.
• Gabbay V, Klein RG, Katz Y, Mendoza S, Guttman LE, Alonso CM, Babb JS, Hirsch GS, Liebes L. The possible role of the kynurenine pathway in adolescent depression with melancholic features. Journal of child psychology & psychiatry & allied disciplines. 2010;51(8):935-943. PMID: 20406333.
• Gabbay V, Liebes L, Katz Y, Liu S, Mendoza S, Babb JS, Klein RG, Gonen O. The kynurenine pathway in adolescent depression: preliminary findings from a proton MR spectroscopy study. Progress in neuro-psychopharmacology & biological psychiatry. 2010;34(1):37-44. PMID: 19778568.
• Gaziel-Sovran, A., M. F. Segura, et al. miR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis. Cancer Cell. 2011 Jul 12;20(1):104-18.PMID: 21741600.
• Gillespie P. A., Kang G. S., Elder A., Gelein R., Chen L., Moreira A. L., Koberstein J., Tchou-Wong K., Gordon T., Chen L.C. Pulmonary response after exposure to inhaled nickel hydroxide nanoparticles: Short and long-term studies in mice. Nanotoxicology. 2010 Mar 1;4(1):106-119. PMID: 20730025.
• Goni F., Prelli F., Ji Y., Scholtzova H., Yang J., Sun Y., Liang F.-X., Kascsak R., Kascsak R., Mehta P. and Wisniewski T. Immunomodulation targeting abnormal protein conformation reduces pathology in a mouse model of alzheimer’s disease. PLoS One. 2010 Oct 13;5(10):e13391. PMID: 20967130.
• Haghpanah J.S., Yuvienco C., Roth E.W., Liang A., Tu R.S., Montclare J.K. Supramolecular assembly and small molecule recognition by genetically engineered protein block polymers composed of two SADs. Mol Biosyst. 2010 Sep;6(9):1662-7. Epub 2010 May 18. PMID: 20480093.
• Hamilton HK, Rose AE, Christos PJ, Shapiro RL, Berman RS, Mazumdar M, Ma MW, Krich D, Liebes L, Brooks PC, Osman I. Increased shedding of HU177 correlates with worse prognosis in primary melanoma. J Transl Med. 2010 Feb 23;8:19. PMID: 20178639.
• Hassenstab JJ, Sweat V, Bruehl H, Convit A. Metabolic syndrome is associated with learning and recall impairment in middle age. Dement Geriatr Cogn Disord. 2010;29(4):356-62. Epub 2010 Apr 24. PMID: 20424454.
• Hernandez-Guillamon M., Mawhirt S., Fossati S., Blais S., Pares M., Penalba A., Boada M., Couraud P.O., Neubert T.A., Montaner J., Ghiso J., Rostagno A. Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-{beta} E22Q and L34V mutants delaying their toxicity for human brain microvascular endothelial cells. J Biol Chem. 2010 Aug 27;285(35):27144-58. Epub 2010 Jun 24. PMID: 20576603.
• Huynh, C., M. F. Segura, et al. Efficient in vivo microRNA targeting of liver metastasis. Oncogene. 2011 Mar 24;30(12):1481-8. Epub 2010 Nov 22. PMID: 21102518.
• Ivanov I.I. and Littman D.R. Segmented filamentous bacteria take the stage. Mucosal Immunol. 2010 May;3(3):209-12. Epub 2010 Feb 10. PMID: 20147894.
• Ivanov S, Goparaju C, Lopez P, Zavadil J, Toren-Haritan G, Rosenwald S, Hoshen M, Chajut A, Cohen D, Pass H. Pro-tumorigenic effects of miR-31 loss in mesothelioma. Journal of biological chemistry. 2010;285(30):22809-22817. PMID: 20463022.
• Haghpanah JS, Yuvienco C, Roth EW, Liang A, Tu RS, Montclare JK. Supramolecular assembly and small molecule recognition by genetically engineered protein block polymers composed of two SADs. Mol Biosyst. 2010 Sep;6(9):1662-7. Epub 2010 May 18. PMID: 20480093.
• Jun G, Naj AC, Beecham GW, Wang LS, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin MD, Friedland R, Inzelberg R, Kramer P, Rogaeva E, St George-Hyslop P; Alzheimer's Disease Genetics Consortium; Cantwell LB, Dombroski BA, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Lunetta KL, Martin ER, MontineTJ, Goate AM, Blacker D, Tsuang DW, Beekly D, Cupples LA, Hakonarson H, Kukull W, Foroud TM, Haines J, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD. Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol. 2010 Dec;67(12):1473-84. Epub 2010 Aug 9. PMID: 20697030.
• Kapoor A, Goldberg MS, Cumberland LK, Ratnakumar K, Segura MF, Emanuel PO, Menendez S, Vardabasso C, Leroy G, Vidal CI, Polsky D, Osman I, Garcia BA, Hernando E, Bernstein E. The histone variant macroH2A suppresses melanoma progression through regulation of CDK8. Nature. Dec 23 2010;468(7327):1105-1109. PMID: 21179167.
• Kara FM, Chitu V, Sloane J, Axelrod M, Fredholm BB, Stanley ER, Cronstein BN. Adenosine A1 receptors (A1Rs) play a critical role in osteoclast formation and function. FASEB J. 2010 Jul;24(7):2325-33. Epub 2010 Feb 24. PMID: 20181934.
• Kara FM, Doty SB, Boskey A, Goldring S, Zaidi M, Fredholm BB, Cronstein BN. Adenosine A(1) receptors regulate bone resorption in mice: adenosine A(1)receptor blockade or deletion increases bone density and prevents ovariectomy-induced bone loss in adenosine A(1) receptor-knockout mice. Arthritis Rheum. 2010 Feb;62(2):534-41. PMID: 20112380.
• Lendvai N, Gnjatic S, Ritter E, Mangone M, Austin W, Reyner K, Jayabalan D, Niesvizky R, Jagannath S, Bhardwaj N, Chen-Kiang S, Old LJ, Cho HJ. Cellular immune responses against CT7 (MAGE-C1) and humoral responses against other cancer-testis antigens in multiple myeloma patients. Cancer imunity. 2010;10:4-4. PMID: 20108890.
• Liu Y., Mo L., Goldfarb D.S., Evan A.P., Liang F., Khan S.R., Lieske J.C., Wu X.-R. Progressive Renal Papillary Calcification and Ureteral Stone Formation in Mice Deficient for Tamm-Horsfall Protein. Am J Physiol Renal Physiol. 2010 Sep;299(3):F469-78. Epub 2010 Jun 30. PMID: 20591941.
• Luo W, Li J, Zhang D, Cai T, Song L, Yin X-M, Desai D, Amin S, Chen J, Huang C. Bid Mediates Anti-Apoptotic COX-2 Induction through the IKKbeta/NFkappaB Pathway Due to 5-MCDE Exposure. Current cancer drug targets. 2010;10(1):96-106. PMID: 20088789.
• Lyon GJ, Samar SM, Conelea C, Trujillo MR, Lipinski CM, Bauer CC, Brandt BC, Kemp JJ, Lawrence ZE, Howard J, Castellanos FX, Woods D, Coffey BJ. Testing tic suppression: comparing the effects of dexmethylphenidate to no medication in children and adolescents with attention-deficit/hyperactivity disorder and Tourette's disorder. J Child Adolesc Psychopharmacol. 2010 Aug;20(4):283-9. PMID: 20807066.
• Ma T, Hoeffer CA, Capetillo-Zarate E, Yu F, Wong H, Lin MT, Tampellini D, Klann E, Blitzer RD, Gouras GK. Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease. PLoS One. 2010 Sep 20;5(9). pii: e12845. PMID: 20862226.
• Manel N, Hogstad B, Wang Y, Levy DE, Unutmaz D, Littman DR. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature. 2010 Sep 9;467(7312):214-7. Erratum in: Nature. 2011 Feb 17;470(7334):424. PMID: 20829794.
• Martiniuk F, Damian DL, Thompson JF, Scolyer RA, Tchou-Wong KM and Levis WR. TH17 is involved in the remarkable regression of metastatic malignant melanoma to topical diphencyprone. J of Drugs in Derm 9,1368-72, 2010. PMID: 21061759.
• Matsumura S, Demaria S. Up-regulation of the Pro-inflammatory Chemokine CXCL16 is a Common Response of Tumor Cells to Ionizing Radiation. Radiation research. 2010;173(4):418-425. PMID:20334513.
• McCarl CA, Khalil S, Ma J, Oh-hora M, Yamashita M, Roether J, Kawasaki T, Jairaman A, Sasaki Y, Prakriya M, Feske S. Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection. J Immunol. Nov 15 2010;185(10):5845-5858. PMID: 20956344.
• Mehta SA, Ahmed A, Kariuki BW, Said S, Omasete F, Mendillo M, Laverty M, Holzman R, Valentine F, Sivapalasingam S. Implementation of a validated peripheral neuropathy screening tool in patients receiving antiretroviral therapy in Mombasa, Kenya. Am J Trop Med Hyg. 2010 Sep;83(3):565-70. PMID: 20810821.
• Mendez O, Zavadil J, Esencay M, Lukyanov Y, Santovasi D, Wang S-C, Newcomb EW, Zagzag D. Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres. Molecular cancer. 2010;9:133-133. PMID: 20515450.
• Newcomb EW, Lukyanov Y, Kawashima N, Alonso-Basanta M, Wang S-C, Liu M, Jure-Kunkel M, Zagzag D, Demaria S, Formenti SC. Radiotherapy Enhances Antitumor Effect of Anti-CD137 Therapy in a Mouse Glioma Model. Radiation research. 2010;173(4):426-432. PMID: 20334514.
• Nonaka, D. Study of parathyroid transcription factor Gcm2 expression in parathyroid lesions. Am J Surg Pathol. 2011 Jan;35(1):145-51. PMID: 21164298.
• Ott PA, Hamilton A, Min C, Safarzadeh-Amiri S, Goldberg L, Yoon J, Yee H, Buckley M, Christos PJ, Wright JJ, Polsky D, Osman I, Liebes L, Pavlick AC. A phase II trial of sorafenib in metastatic melanoma with tissue correlates. PLoS One. 2010;5(12):e15588. PMID: 21206909.
• Peng Y, Li Y, Gellert LL, Zou X, Wang J, Singh B, Xu R, Chiriboga L, Daniels G, Pan R, Zhang DY, Garabedian MJ, Schneider RJ, Wang Z, Lee P. Androgen receptor coactivator p44/Mep50 in breast cancer growth and invasion. J Cell Mol Med. Dec 2010;14(12):2780-2789. PMID: 19840198.
• Reavie L, Della Gatta G, Crusio K, Aranda-Orgilles B, Buckley SM, Thompson B, Lee E, Gao J, Bredemeyer AL, Helmink BA, Zavadil J, Sleckman BP, Palomero T, Ferrando A, Aifantis I. Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex. Nat Immunol. 2010 Mar;11(3):207-15. Epub 2010 Jan 17. PMID: 20081848.
• Roignant JY, Treisman JE. Exon junction complex subunits are required to splice Drosophila MAP kinase, a large heterochromatic gene. Cell. 2010 Oct 15;143(2):238-50. PMID: 20946982.
• Sabbaghian, M. S., G. Rothberger, et al. Levels of elevated circulating endothelial cell decline after tumor resection in patients with pancreatic ductal adenocarcinoma. Anticancer Res. 2010 Jul;30(7):2911-7. PMID: 20683032.
• Sadri N, Lu J-Y, Badura ML, Schneider RJ. AUF1 is involved in splenic follicular B cell maintenance. BMC Immunology. 2010;11:1-1. PMID: 20064252.
• Simpson NE, Lambert WM, Watkins R, Giashuddin S, Huang SJ, Oxelmark E, Arju R, Hochman T, Goldberg JD, Schneider RJ, Reiz LF, Soares FA, Logan SK, Garabedian MJ. High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance. Cancer Res. Nov 1 2010;70(21):8446-8456. PMID: 20847343.
• Sirikanjanapong S, Lanson B, Amin M, Martiniuk F, Kamino H and Wang BY. Collision Tumor of Primary Laryngeal Mucosal Melanoma and Invasive Squamous Cell Carcinoma with IL-17A and CD70 Gene Over-Expression. Head Neck Pathol 4:295-9, 2010. PMID: 20697851.
• Su H., Marcheva B., Meng S., Liang, F., Kohsaka A., Kobayashi Y., Xu A.-W., Bass J. and Wang X. Gamma-protocadherins regulate the functional intergrity of hypothalamic feeding circuitry in mice. Dev Biol. 2010 Mar 1;339(1):38-50. Epub 2009 Dec 16. PMID: 20025866.
• Vardhana S, Choudhuri K, Varma R, Dustin M. Essential Role of Ubiquitin and TSG101 Protein in Formation and Function of the Central Supramolecular Activation Cluster. Immunity. 2010;32(4):531-540. PMID: 20399684.
• Vazquez-Cintron EJ, Monu NR, Frey AB. Tumor-induced disruption of proximal TCR-mediated signal transduction in tumor-infiltrating CD8+ lymphocytes inactivates antitumor effector phase. J Immunol. Dec 15 2010;185(12):7133-7140. PMID: 21127315.
• Victora GD, Schwickert TA, Fooksman DR, Kamphorst AO, Meyer-Hermann M, Dustin ML, Nussenzweig MC. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell. 2010 Nov 12;143(4):592-605. PMID: 21074050.
• Williams SC, Karajannis MA, Chiriboga L, Golfinos JG, von Deimling A, Zagzag D. R132H-mutation of isocitrate dehydrogenase-1 is not sufficient for HIF-1α upregulation in adult glioma. Acta Neuropathol. 2011 Feb;121(2):279-81. Epub 2010 Dec 24. PMID: 21181477.
• Wu J, Henderson C, Feun L, Van V, Gold P, Zheng H, Ryan T, Blaszkowsky L, Chen H, Costa M, Rosenzweig B, Nierodzik M, Hochster H, Muggia F, Abbadessa G, Lewis J, Zhu A. Phase II study of darinaparsin in patients with advanced hepatocellular carcinoma. Investigational new drugs. 2010;28(5):670-676. PMID: 19565187.
• Wu X, Chen F, Sahin A, Albarracin C, Pei Z, Zou X, Singh B, Xu R, Daniels G, Li Y, Wei J, Blake M, Schneider RJ, Cowin P, Lee P. Distinct function of androgen receptor coactivator ARA70alpha and ARA70beta in mammary gland development, and in breast cancer. Breast Cancer Res Treat. 2011 Jul;128(2):391-400. Epub 2010 Sep 3.. PMID: 20814820.
• Wu, X., G. Daniels, et al. LEF1 identifies androgen-independent epithelium in the developing prostate. Mol Endocrinol. 2011 Jun;25(6):1018-26. Epub 2011 Apr 28. PMID: 21527502.
• Yang M, Nonaka D. A study of immunohistochemical differential expression in pulmonary and mammary carcinomas. Mod Pathol. 2010 May;23(5):654-61. Epub 2010 Feb 19. PMID: 20173733.
• Zanin-Zhorov A, Ding Y, Kumari S, Attur M, Hippen KL, Brown M, Blazar BR, Abramson SB, Lafaille JJ, Dustin ML. Protein kinase C-theta mediates negative feedback on regulatory T cell function. Science. 2010;328(5976):372-376. PMID: 20339032.
• Zavadil J, Ye H, Liu Z, Wu J, Lee P, Hernando E, Soteropoulos P, Toruner GA, Wei JJ. Profiling and functional analyses of microRNAs and their target gene products in human uterine leiomyomas. PLoS One. 2010;5(8):e12362. PMID: 20808773.
• Zhou X, Sun H, Chen H, Zavadil J, Kluz T, Arita A, Costa M. Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase. Cancer research. 2010;70(10):4214-4221. PMID: 20406991.
• Zito E, Chin KT, Blais J, Harding HP, Ron D. ERO1-β, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis. J Cell Biol. 2010 Mar 22;188(6):821-32. J Cell Biol. 2010 May 17;189(4):769. PMID: 20308425.